Radioactive metals complexed with phosphonate derivatives of...

C - Chemistry – Metallurgy – 07 – F

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260/426, 167/47

C07F 9/38 (2006.01) A61K 51/04 (2006.01) C07F 13/00 (2006.01) G01N 33/60 (2006.01)

Patent

CA 1227214

ABSTRACT OF THE DISCLOSURE Complexes of radionuclides with a compound of the formula -IMAGE- wherein substituents A, B, X and Y are each independently selected from radicals including hydrogen; hydroxyalkyl (wherein the alkyl group contains 2-6 carbon atoms); phosphonic; sulfonic; methylenephosphonic; methylene-, ethylene-, and propylene-sulfonic; carboxylic acid radicals (having 2-4 carbon atoms); and the alkali metal, alkaline earth metal, ammonia, or amine salts thereof; and wherein at least one of A, B, X, and Y is methylene- phosphonic acid or a salt thereof. Tc-99m complexes have been found useful for imaging the skeletal structure of animals.

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