Radioactive phosphorous labeling of proteins for targeted...

Details Radioactive phosphorous labeling of proteins for targeted... Radioactive phosphorous labeling of proteins for targeted...

C - Chemistry, Metallurgy

07

K

C07K 17/06 (2006.01) A61K 51/08 (2006.01) A61K 51/10 (2006.01) C07K 1/13 (2006.01) C07K 16/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2200855

32P- and 33P-labeled proteins which are useful for radiotherapy are prepared by stably linking 32P- or 33P- containing molecules to targeting proteins in such a way that the targeting protein retains the ability to bind to a celular target. Methods for preparing the labeled proteins and their use in methods of radiotherapy are described.

On prépare des protéines marquées par <32>P et <33>P, efficaces en radiothérapie, par réalisation d'une liaison stable de molécules contenant <32>P ou <33>P à des protéines de ciblage, de telle façon que les protéines de ciblage conservent leur capacité de fixation à des cellules cibles. L'invention concerne également des procédés de préparation des protéines marquées, ainsi que leur utilisation dans des procédés de radiothérapie.

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