C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/06 (2006.01) A61K 47/48 (2006.01) A61K 49/06 (2006.01) A61K 49/10 (2006.01) A61K 51/04 (2006.01) C07H 19/073 (2006.01) C07K 1/13 (2006.01) C07K 7/02 (2006.01)
Patent
CA 2679514
The present invention relates to radiolabelled substitute benzene compounds for diagnostic imaging. The present invention provides methods for preparation of such compounds, in particular, preparation of novel compounds which serve as precursors for 18F-labeling, and the use of thus 18F-labe!ed compounds for diagnostic imaging. Formula (A), wherein one of -Y1, -Y2, -Y3 Y4 and -Y5 is -A-B-D-P, wherein -A-B-D- is a bond or spacer, P is peptide, peptidomimetic, oligonucleotide or small molecule. K is LG-O or W, wherein: LG- is selected from the group comprising Formula (B), wherein T is H or Cl, Q is CH or N, K is absent or is C=O. W is radioactive or non-radioactive isotope of fluorine, more preferably 18F.
La présente invention concerne des composés de benzène substitués radiomarqués pour l'imagerie diagnostique. La présente invention concerne des procédés de préparation de tels composés, en particulier, la préparation de nouveaux composés qui servent de précurseurs pour le marquage au 18F, ainsi que l'utilisation de tels composés marqués au 18F pour l'imagerie diagnostique.
Srinivasan Ananth
Stellfeld Timo
Bayer Schering Pharma Aktiengesellschaft
Marks & Clerk
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