Radiographic scanning agent

Details Radiographic scanning agent Radiographic scanning agent

A - Human Necessities

61

K

167/48

A61K 49/00 (2006.01) A61K 51/04 (2006.01) C07F 9/02 (2006.01) C07F 9/38 (2006.01) G01T 1/00 (2006.01)

Patent

CA 1143285

RADIOGRAPHIC SCANNING AGENT Abstract A composition and method for the preparation of a technetium-99m-based scanning agent are disclosed. The scanning agent is prepared from 99mTc, in a +3, +4 and/or +5 oxidation state, and a methanehydroxydiphosphonate bone-seeking agent which carries the radionuclide to bone mineral. The methanehydroxydiphosphonate agent provides scan sharpness equivalent or superior to commercial scanning agents, and is superior for detecting myocardial infarcts, as compared with commercial scanning agents such as ethane-1-hydroxy-1,1-diphosphonate and methane- diphosphonate.

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