Radioimaging probes and the use thereof

C - Chemistry – Metallurgy – 07 – J

Patent

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Details

C07J 41/00 (2006.01) A61K 49/04 (2006.01) A61K 51/04 (2006.01) C07J 9/00 (2006.01)

Patent

CA 2411586

The present invention provides novel radioimaging probes for use in combination with clinical radioimaging techniques for the visualization of specific tissues or regions of the body. These probes can be packaged into a blood-borne delivery vehicle for targeted delivery to these specific tissues or regions. This invention further provides for the use of synthetic microemulsions or chemically modified human low-density lipoprotein (LDL), such as acetylated LDL (AcLDL), as delivery vehicles to target the radioimaging probes specifically to tissues or regions that contain high concentrations of LDL receptors.

La présente invention concerne de nouvelles sondes de radioimagerie qui sont utilisées en combinaison avec des techniques de radioimagerie clinique pour visualiser des tissus ou des régions spécifiques du corps. Les sondes de l'invention peuvent être incorporées dans un véhicule circulant dans le sang afin de permettre une délivrance ciblée aux tissus et régions spécifiques précités. L'invention concerne en outre l'utilisation de microémulsions synthétiques ou d'une lipoprotéine de basse densité (LDL) humaine chimiquement modifiée telle qu'une LDL acétylée (AcLDL) comme véhicules pour cibler spécifiquement les sondes de radioimagerie sur des tissus ou des régions à haute concentration en récepteurs de LDL.

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