Radioimmunoassay of pterins and novel pterin derivatives...

C - Chemistry – Metallurgy – 07 – D

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C07D 475/02 (2006.01) C07D 239/48 (2006.01) C07D 475/04 (2006.01) G01N 33/534 (2006.01) G01N 33/82 (2006.01)

Patent

CA 1150243

ABSTRACT OF THE DISCLOSURE Pterin derivatives are described having the formula (I) Image (I) wherein R represents a hydroxyphenyl group, a radio-iodinated hydroxyphenyl group, a tyraminocarbonyl group, a radioiodinated tyraminocarbonyl group, a proteinocarbonyl group or a carboxy group; Q represents a straight or branched chain alkylene group having having 1 to 6 carbon atoms; and R6 and R7 each represents a hydrogen, an alkyl group having from 1 to 6 carbon atoms, a hydroxyalkyl group having from 1 to 6 carbon atoms; and a radio- immunoassay method is described using a radioiodinated 4-hydroxy- 2-tyraminopteridine derivative or a radioiodinated 4-hydroxy-2- tyraminocarbonylalkylaminopteridine derivative as the tracer.

355429

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