Radioiodinated benzamides and method of their use as...

Details Radioiodinated benzamides and method of their use as... Radioiodinated benzamides and method of their use as...

C - Chemistry, Metallurgy

07

D

167/47, 260/325.

C07D 207/09 (2006.01) A61K 49/02 (1990.01)

Patent

CA 1331007

ABSTRACT Novel, substituted benzamides in radioiodinated form are useful in radiopharmaceutical compositions in nuclear medi- cine as imaging agents to detect, visualize, and analyze the distribution and function of the dopamine D-2 receptor in the mammalian brain. The substituted benzamides and their racemic mixtures or their optically resolved enantiomers can be made by reacting a trialyltin substituted benzamide with an acid in the presence of radioactive iodine, generated by in situ oxidation of an appropriate iodide nuclide salt.

583258

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