Radioisotope concentrator methods and compositions

Details Radioisotope concentrator methods and compositions Radioisotope concentrator methods and compositions

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 38/46 (2006.01) A61K 48/00 (2006.01) A61K 51/04 (2006.01) A61K 51/12 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01) C12N 9/16 (2006.01) C12N 15/55 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2286860

The present invention pertains to combination nuclear medicine involving radiopharmaceuticals for diagnostic imaging and for therapy of tumors. More specifically the invention includes pharmaceutical compositions and methods of treatment, diagnosis, and radioimaging by genetic engineering designed to accumulate radioisotopes in cells. The combination of genetic engineering to confer radioisotope accumulation by cells with introduction of radioisotopes has many uses including radioimaging in vitro or in vivo to locate or identify gene expression, radiation therapy for killing neoplastic and non-neoplastic cells, and diagnostic applications. Genetic constructs, vectors, transformed cells and methods are disclosed.

La présente invention concerne la médecine nucléaire d'association faisant intervenir des agents radio-pharmaceutiques destinés à l'imagerie diagnostique et à la thérapie des tumeurs. Plus spécifiquement, l'invention concerne des compositions pharmaceutiques et des méthodes de traitement, de diagnostic et de radio-imagerie par génie génétique conçues pour accumuler des radio-isotopes dans des cellules. L'association du génie génétique pour conférer une accumulation de radio-isotope par des cellules avec l'introduction de radio-isotopes présente de nombreuses utilisations et notamment la radio-imagerie in vitro ou in vivo afin de localiser ou d'identifier l'expression de gènes, la radiothérapie destinée à tuer des cellules néoplasique et non néoplasiques, et des applications diagnostiques. L'invention concerne également des constructions génétiques, des vecteurs, des cellules transformées et des méthodes.

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