Radiolabeled annexins

A - Human Necessities – 61 – K

Patent

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Details

A61K 51/08 (2006.01) C07K 14/47 (2006.01) G01T 1/161 (2006.01)

Patent

CA 2735214

A radiolabeled annexin comprising at least 2 up to 20 histidine residues at its N-terminus is disclosed. At least two of said histidine residues are adjacent or separated by no more than one other amino acid. The radiolabeled annexin is a stable complex with a radionuclide such as technetium 99m. The radiolabeled annexin can be used in a method of imaging cell death in a nucleated cell within a region of a mammalian subject in vivo.

La présente invention concerne une annexine radiomarquée comprenant au moins 2 et jusqu'à 20 résidus d'histidine au niveau de son extrémité N-terminale. Au moins deux desdits résidus d'histidine sont contigus ou séparés, mais pas, par plus d'un autre acide aminé. Cette annexine radiomarquée forme un complexe stable avec un radionucléide tel que le technétium 99m. Cette annexine radiomarquée peut être utilisée dans un procédé d'imagerie de la mort cellulaire d'une cellule nucléée présente au sein d'une région d'un sujet mammifère in vivo.

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