Radiolabeled antibody fragments

Details Radiolabeled antibody fragments Radiolabeled antibody fragments

A - Human Necessities

61

K

167/40, 195/1.1

A61K 51/10 (2006.01) C07D 207/452 (2006.01)

Patent

CA 1276878

ABSTRACT OF THE DISCLOSURE Methods and reagents for attaching radionuclide metal ions to antibody fragments are disclosed. A coupling agent is employed which contains a maleimidyl group linked, through a divalent organic moiety, to a group capable of forming a chelate complex with the radionuclide metal ion. Antibody fragments labeled with radionuclide metal ions by the disclosed procedure are useful for in vivo diagnostic or therapeutic applications.

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