Radiolabeled cannabinoid-1 receptor modulators

Details Radiolabeled cannabinoid-1 receptor modulators Radiolabeled cannabinoid-1 receptor modulators

C - Chemistry, Metallurgy

07

D

C07D 213/64 (2006.01) A61K 51/04 (2006.01) C07D 239/34 (2006.01)

Patent

CA 2530087

The present invention relates to particular radiolabeled Cannabinoid-1 (CB1) receptor modulators, and methods of using these modulators for labeling and diagnostic imaging of Cannabinoid-1 receptors in mammals, particularly humans. In addition, intermediates useful for the synthesis of the radiolabeled Cannabinoid-1 receptor modulators are also disclosed, as well as the processes for synthesizing the radiolabeled Cannabinoid-1 receptor modulators. Still further, formulations of the radiolabeled Cannabinoid-1 receptor compounds are described.

L'invention concerne des modulateurs radiomarqués particuliers du récepteur du cannabinoïde-1 (CB1) et des procédés d'utilisation de ces modulateurs pour le marquage et l'imagerie diagnostique des récepteurs de cannabinoïde-1 chez les mammifères, notamment chez les humains. En outre, l'invention concerne des intermédiaires utilisés dans la synthèse des modulateurs radiomarqués du récepteur de cannabinoïde-1, ainsi que les processus permettant de synthétiser lesdits modulateurs. Elle concerne enfin des formulations des composés radiomarqués du récepteur de cannabinoïde-1.

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