C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/04 (2006.01) A61K 51/04 (2006.01) A61K 51/06 (2006.01) C07B 59/00 (2006.01) C07D 475/04 (2006.01) C07D 495/04 (2006.01) G01T 1/161 (2006.01)
Patent
CA 2555597
Positron emitting compounds and methods of their production are provided. The compounds have the formula: (F)m G (R)n wherein each R is a group comprising at least one carbon, nitrogen, phosphorus or sulfur atom and G is joined to R through said carbon, nitrogen, phosphorus or sulfur atom; G is silicon or boron; m is 2 to 5 and n is 1 to 3 with m + n = 3 to 6 when G is silicon; m is 1 to 3 and n is 1 to 3 with m + n = 3 to 4 when G is boron; and wherein the compound further comprises one or more counterions when the above formula is charged; and wherein at least one F is 18F.
La présente invention a trait à des composés d'émission de positrons et leurs procédés de production. Les composés sont de formule : (F)¿m? G (R)¿n? dans laquelle chaque R est un groupe comportant au moins un atome de carbone, d'azote, de phosphore ou de soufre et G est lié à R par l'atome de carbone, d'azote, de phosphore ou de soufre ; G est du silicium ou du bore ; m est compris entre 2 et 5 et n est compris entre 1 et 3 et m + n = 3 à 6 lorsque G est du silicium ; m est compris entre 1 et 3 et n est compris entre 1 et 3 et m + n = 3 à 4 lorsque G est du bore ; et le composé comportant en outre un ou des contre-ions lorsque ladite formule est chargée ; et au moins un F étant ?18¿F.
Perrin David M.
Ting Richard
Smart & Biggar
The University Of British Columbia
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