Radiolabeled compounds for thrombus imaging

Details Radiolabeled compounds for thrombus imaging Radiolabeled compounds for thrombus imaging

A - Human Necessities

61

K

A61K 51/08 (2006.01)

Patent

CA 2191949

This invention relates to radiolabeled scintigraphic imaging agents, and methods and reagents for producing such agents. Specifically, the invention relates to specific binding compounds, including peptides, that bind to a platelet receptor that is the platelet GPIIb/IIIa receptor, methods and kits for making such compounds, and methods for using such compounds labeled with technetium-99m via a covalently-linked radiolabel-binding moiety to image thrombi in a mammalian body.

L'invention concerne des agents pour images scintigraphiques radiomarquées, et des procédés et des réactifs pour produire ces agents. De manière spécifique, l'invention concerne des composés de liaison spécifiques, comprenant des peptides, qui se lient à un récepteur de plaquettes, le récepteur de plaquette GPIIb/IIIa. Elle traite également de procédés et de kits pour produire ces composés, et de procédés pour utiliser ces composés marqués au technetium-99m via une fraction de liaison de radiomarquage liée par covalence pour représenter des thrombi dans un corps de mammifère.

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