Radiolabeled conjugates based on substance p and the uses...

Details Radiolabeled conjugates based on substance p and the uses... Radiolabeled conjugates based on substance p and the uses...

A - Human Necessities

61

K

A61K 51/08 (2006.01)

Patent

CA 2519315

Radionuclide labelled conjugates based on substance P and analogues thereof with the chelator (DOTAGA) (1 -(1 -rarboxy-3-carboxy-propyl)-4,7, 10(carboxymethyl)- 1,4,7,10-tetraazacyclo-dodecane, DOTASA (1 -(1 -carboxy- 2~carboxy-ethyl)-4,7, 10 (carboxymethyl)1,4,7, 10-tetraazacyclo-dodecane, or chelator (DOTA) [1,4,7, 10 ~tetraazaacyclo-dodecane1,4,7, 1 0-tetra(acetie acid)] are useful rad iopharmaceutical substa nces for targeting and treatment of brain tumors, especially gliomas.

Conjugués marqués par des radionucléides basés sur la substance P et sur des analogues de ladite substance avec le chélateur (DOTAGA) (1-(1-carboxy-3-carboxy-propyl)-4,7,10(carboxyméthyl)-1,4,7,10-tétraazacyclo-dodécane, DOTASA (1-(1-carboxy-2-carboxy-éthyl)-4,7,10(carboxyméthyl)-1,4,7,10-tétraazacyclo-dodécane, ou avec le chélateur (DOTA) [1,4,7,10-tétraazaacyclo-dodécane-1,4,7,10-tétra(acide acétique)] qui sont utiles en tant que produits radiopharmaceutiques pour cibler et traiter des tumeurs cérébrales, en particulier des gliomes.

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