C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/18 (2006.01) A61K 51/10 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) C07K 1/13 (2006.01) C07K 16/00 (2006.01)
Patent
CA 2702618
This application discloses methods for producing radiolabeled IgM or IgA monoclonal antibodies using tris(2-car-boxyethyl) phosphine hydrochloride (TCEP) to reduce disulfide bonds to generate sulfhydryl (-SH) groups and treating the monoclonal antibody with a radioisotope that binds to -SH groups, radiolabeled antibodies produced by the methods, monoclonal antimelanin IgM antibodies containing about 42 to about 45 -SH groups, and methods of treating and imaging cancer, such an melanoma, and infections using the radiolabeled antibodies.
Cette invention concerne des procédés de production d'anticorps monoclonaux IgM ou IgA marqués à l'aide de chlorhydrate de tris(2-carboxyéthyl)-phosphine (TCEP) pour réduire les liaisons disulfures pour générer des groupes sulfhydryles (-SH), et de traitement de l'anticorps monoclonal par un radio-isotope qui se lie à des groupes -SH. L'invention concerne également des anticorps marqués obtenus par les procédés, des anticorps monoclonaux IgM anti-mélanine contenant d'environ 42 à 45 groupes -SH et des procédés de traitement et d'imagerie d'un cancer, tel qu'un mélanome, et d'infections à l'aide des anticorps marqués.
Casadevall Arturo
Dadachova Ekaterina
Damania Hema
Sesay Muctarr A.
Smariga Paulette E.
Albert Einstein College Of Medicine Of Yeshiva University
Goodwin Biotechnology Inc.
Osler Hoskin & Harcourt Llp
Pain Therapeutics Inc.
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