Radiolabeled nanohybrids targeting solid tumor...

A - Human Necessities – 61 – K

Patent

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A61K 51/00 (2006.01)

Patent

CA 2572226

Nanohybrid polymer conjugates that provide a ~platform~ delivery system is disclosed. The delivery platform provides a multi-focused therapeutic regimen that may be tailored to combat a host of cancers, including advanced-stage, therapy-resistant tumors. The nanohybrids of the instant invention incorporate a configurable polymeric backbone, are multivalent (e.g., may incorporate several targeting ligands), and have the capacity to carry multiple classes of ~payloads~ (e.g., alpha-, beta-, gamma- and positron- emitting isotopes). The polymer conjugates comprise a single molecular species that can be useful not only in diagnostic assessment, but also in tailoring therapies to suit a variety of cancers.

L'invention concerne des conjugués polymères nanohybrides qui produisent un système de distribution à plate-forme. Ladite plate-forme de distribution comprend des régimes thérapeutiques à plusieurs foyers qui peuvent être personnalisés pour combattre un hôte de cancers, notamment des tumeurs résistant à une thérapie et à un état avancé. Les nanohybrides de l'invention incorporent un squelette polymère configurable, ils sont multivalents (par exemple, ils peuvent comprendre plusieurs ligands cibles), et présenter une capacité à supporter de nombreuses classes de charges utiles (par exemple des isotopes émettant des rayons alpha, bêta, gamma et positron). Les conjugués polymères comprennent des espèces moléculaires simples qui peuvent être utilisées non seulement dans l'évaluation diagnostique, mais également dans des thérapies personnalisées pour soigner une pluralité de cancers.

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