Radiolabeled proteins for diagnostic or therapeutic use

Details Radiolabeled proteins for diagnostic or therapeutic use Radiolabeled proteins for diagnostic or therapeutic use

C - Chemistry, Metallurgy

07

K

C07K 17/06 (2006.01) A61K 39/44 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) C07D 207/46 (2006.01) C07D 309/08 (2006.01) C07K 1/13 (2006.01) C07K 5/06 (2006.01) C07K 5/083 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2046654

Chelating compounds of specified structure are useful for radiolabeling targeting molecules such as antibodies. Cleavable linkers connect the radionuclide metal chelates to the antibodies. The radiolabeled antibodies have improved biodistribution pro- perties, including reduced localization within the intestines and kidneys.

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