Radiolabeled somatostatin-derived peptides for imaging

Details Radiolabeled somatostatin-derived peptides for imaging Radiolabeled somatostatin-derived peptides for imaging

C - Chemistry, Metallurgy

07

K

C07K 14/655 (2006.01) A61K 51/08 (2006.01)

Patent

CA 2347670

This invention relates to therapeutic reagents and peptides, including radiotherapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing labeled radiodiagnostic agents. Specifically, the invention relates to cyclic peptide derivatives and analogues of somatostatin, and embodiments of such peptides radiolabeled with a radioisotope, as well as methods and kits for making, radaolabeling and using such peptides for radiodiagnostic and radiotherapeutic purposes. The invention specifically relates to cyclic peptide derivatives and analogues of somatostatin radiolabeled with technetium-99m and uses thereof as scintigraphic imaging agents. The invention also specifically relates to cyclic peptide derivatives and analogues of somatostatin radiolabeled with cytotoxic radioisotopes such as rhenium-186 (186Re) and rhenium-188 (188Re) for use as radiotherapeutic agents. Methods and kits for making, radiolabeling anal using such peptides diagnostically and therapeutically in a mammalian body are also provided.

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