Radiolabelled fluorobenzamide analogues, their synthesis and...

Details Radiolabelled fluorobenzamide analogues, their synthesis and... Radiolabelled fluorobenzamide analogues, their synthesis and...

C - Chemistry, Metallurgy

07

D

C07D 217/04 (2006.01) A61B 6/00 (2006.01) A61K 51/00 (2006.01) C07B 59/00 (2006.01)

Patent

CA 2689141

Fluoroalkoxybenzamide compounds which selectively bind Sigma-2 receptors are disclosed. These compounds, when labelled with 18F, can be used as radiotracers for imaging of tumors by positron emission tomography (PET). In addition, these compounds, when labelled with 123I, can be used as radiotracers for imaging of tumors by single photon emission computed tomography (SPECT). Methods for synthesis of these compounds are also disclosed.

L'invention concerne des composés de fluoroalcoxybenzamide se liant de façon sélective à des récepteurs Sigma-2. Ces composés, lorsqu'ils sont marqués par 18F, peuvent servir d'indicateurs radioactifs dans l'imagerie des tumeurs par tomographie par émission de positons (TEP). En outre, ces composés, lorsqu'ils sont marqués par 123I, peuvent servir d'indicateurs radioactifs dans l'imagerie des tumeurs par tomographie informatisée par émission monophotonique (TEM). L'invention concerne également des procédés de synthèse de ces composés.

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