Radiolabelling

Details Radiolabelling Radiolabelling

C - Chemistry, Metallurgy

07

F

C07F 13/00 (2006.01) A61K 51/04 (2006.01) A61K 51/10 (2006.01) C07B 59/00 (2006.01) C07C 229/12 (2006.01) C07C 229/22 (2006.01) C07K 16/18 (2006.01) G01N 33/534 (2006.01)

Patent

CA 2094380

The ligand L. (R3)(R4)(R5)C-N(R)-C(R1)(R2)-(CH2)n-COOH L where R is hydrogen, hydroxy, alkyl, hydroxyalkyl, or alkylcarboxy, or R and R1 together may form a mono-, di-, tri-, or tetra-methylene radical, or R and R3 together may form a mono-, di-, tri-, or tetra-methylene radical, and R1 and R2 may be the same or different and are selected from hydrogen, hydroxy, alkyl, hydroxyalkyl, carboxy, alkylcarboxy, alkylamine, alkylthiol, aryl or R1 and R2 together may form a tetra- or penta-methylene radical, and R3 and R4 and R5 may be the same or different and are selected from hydrogen, hydroxy, alkyl, hydroxyalkyl, carboxy, alkylcarboxy, provided that at least one of R3, R4 and R5 is hydroxyalkyl, and n is equal to 0, 1 or 2, for example tricine, form useful complexes with 99m Tc, for radiolabelling macromolecules such as monoclonal antibodies.

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