Radiolabelling of proteins

Details Radiolabelling of proteins Radiolabelling of proteins

C - Chemistry, Metallurgy

12

P

167/101, 530/7.0

C12P 21/02 (2006.01) A61K 51/08 (2006.01) A61K 51/10 (2006.01) C07K 1/13 (2006.01) C07K 7/06 (2006.01) C07K 16/00 (2006.01) C07K 16/40 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1338860

A method is provided for attaching 32P to a protein, normally an antibody, that will bind with and irradiate a tumour-associated structure leading to therapeutic benefit. The invention is based upon the introduction of a peptide region to the protein, which is capable of acting as a substrate for a phosphokinase utilising 32P-.gamma.-ATP as a typical source of the radionuclide. The conjugation of the substrate molecule to the protein may be achieved by chemical methods or by genetic engineering techniques. Novel substrate peptides are disclosed.

534597

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