Radiometal-binding analogues of luteinizing hormone...

Details Radiometal-binding analogues of luteinizing hormone... Radiometal-binding analogues of luteinizing hormone...

C - Chemistry, Metallurgy

07

K

C07K 7/23 (2006.01) A61K 38/09 (2006.01) A61K 51/08 (2006.01) C07K 1/13 (2006.01) C07K 7/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2223432

Peptide derivatives of luteinizing hormone releasing hormone that are capable of binding radionuclides are provided. The peptide derivatives are readily labeled with isotopes of rhenium or technetium, while retaining their ability to tightly bind LHRH receptors. Methods for preparing the labeled peptides and their use in methods of radiodiagnosis and radiotherapy are described.

L'invention porte sur des dérivés de peptide de l'hormone libérant l'hormone lutéinisante (LHRH) capables de fixer des radionuclides. Ces dérivés peptidiques se laissent aisément marquer au moyen d'isotopes de rhénium ou de technétium tout en conservant leur aptitude à se lier étroitement à des récepteurs de LHRH. L'invention porte également sur des procédés de production de peptides marqués ainsi que sur leur utilisation dans le cadre de techniques radiodiagnostiques et radiothérapiques.

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