Radiometal complexes that localise in hypoxic tissue

Details Radiometal complexes that localise in hypoxic tissue Radiometal complexes that localise in hypoxic tissue

C - Chemistry, Metallurgy

07

C

C07C 251/38 (2006.01) A61K 51/04 (2006.01) C07B 59/00 (2006.01) C07C 251/36 (2006.01) C07D 233/28 (2006.01) C07D 233/91 (2006.01) C07F 13/00 (2006.01) C07F 15/00 (2006.01)

Patent

CA 2168652

The invention concerns ligands, e.g. based on alkylene amine oxime particularly butylene amine oxime ring structures, and radiometal complexes thereof. The radiometal complexes are intrinsically capable of localising in tumours or hypoxic tissue and can be used in imaging or radiotherapy.

L'invention concerne des ligands, par exemple ceux à base d'alkylène amine oxime et notamment de structures cycliques de butylène amine oxime, ainsi que certains de leurs complexes radiométalliques. Ces derniers offrent la capacité intrinsèque de se fixer dans des tumeurs ou des tissus hypoxiques et on peut les utiliser pour l'imagerie ou la radiothérapie.

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