Radionuclide metal chelates for the radiolabeling of...

Details Radionuclide metal chelates for the radiolabeling of... Radionuclide metal chelates for the radiolabeling of...

C - Chemistry, Metallurgy

07

K

C07K 5/06 (2006.01) A61K 51/04 (2006.01) A61K 51/10 (2006.01) C07B 59/00 (2006.01) C07D 495/04 (2006.01) C07F 1/08 (2006.01) C07F 13/00 (2006.01) C07F 15/00 (2006.01) C07H 5/06 (2006.01) C07H 23/00 (2006.01) C07K 5/078 (2006.01) C07K 9/00 (2006.01)

Patent

CA 2165052

Chelating compounds of specified structure are useful for radiolabeling targeting proteins such as antibodies as well as proteinaceous and non-proteinaceous ligands and anti-ligands. The radiolabeled antibodies, ligands or anti-ligands, or catabolites thereof, demonstrate improved biodistribution properties, including reduced localization within the intestines.

Des composés chelatants présentant une structure spécifique sont efficaces pour le radiomarquage de protéines de ciblage, tels que des anticorps, ainsi que des ligands et anti-ligands protéiniques et non-protéiniques. Les anticorps, ligands ou anti-ligands radiomarqués, ou leurs catabolites, possèdent des propriétés améliorées de biodistribution, y compris une localisation réduite dans les intestins.

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