A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/101, 167/119
A61K 51/04 (2006.01)
Patent
CA 1190473
A B S T R A C T Radiopharmaceutical compositions containing complexes of technetium-99m with a complexing agent are prone to lime and activity-related decomposition and formation of pertechnetate. Stabilizing agents for such complexes are organic compounds having a amine group and a carboxylic acid group attached to an aromatic ring. A preferred stabilizing agent is the sodium salt of 4-aminobenzoic acid. There are claims to a composition comprising a technetium 99-m complex stabilized by means of the said stabilizing agent; and to a reagent which forms, on addition of an aqueous solution of pertechnetate, a radiopharmaceutical composition, which reagent comprises a tin metal or stannous reducing agent for the pertechnetate, a complexing agent for the reduced technetium, for example a phosphorus-containing bone scanning agent, and a stabilizing agent as defined.
414271
Amersham International Plc
Ridout & Maybee Llp
LandOfFree
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