A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 51/04 (2006.01) A61K 51/02 (2006.01)
Patent
CA 2417392
A radiopharmaceutical for diagnostic imaging containing as an active ingredient a technetium-99m nitride heterocomplex comprising technetium-99m nitride and two different ligands coordinated therewith, i.e., a bisphosphinoamine compound as a .pi. electron acceptor and a bidentate ligand as a .pi. electron donor and represented by the following formula (1): [99mTc(N)(PNP)(XY)]+ (1)wherein 99mTc(N) is technetium-99m nitride, PNP is a bisphosphinoamine compound and XY is a bidentate ligand, is markedly accumulated in heart and adrenal glands and hence is useful for radiodiagnostic imaging of heart and adrenal glands.
L'invention concerne une substance radiopharmaceutique pour imagerie de diagnostic renfermant comme principe actif un hétérocomplexe au nitrure de technetium-99m, qui comporte du niture de technetium-99m et deux ligands différents coordonnés avec le nitrure, à savoir un composé de bisphosphinoamine accepteur d'électrons .pi. et un ligand bidenté comme donneur d'électrons .pi. selon la formule (1). Dans cette formule, ?99m¿Tc(N) est le nitrure de technetium-99m, PNP est un composé de bisphosphinoamine et XY est un ligand bidenté. L'accumulation de cette substance est marquée dans le coeur et les glandes surrénales, d'où l'utilité de ladite substance pour l'imagerie de radiodiagnostic concernant le coeur et les glandes surrénales.
Bolzati Cristina
Boschi Alessandra
Duatti Adriano
Refosco Fiorenzo
Tisato Francesco
Marks & Clerk
Nihon Medi-Physics Co. Ltd.
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