Radioprotectant for peptides labeled with radioisotope

Details Radioprotectant for peptides labeled with radioisotope Radioprotectant for peptides labeled with radioisotope

A - Human Necessities

61

K

A61K 51/10 (2006.01) A61K 47/12 (2006.01) A61K 47/32 (2006.01) A61K 51/08 (2006.01) A61P 35/00 (2006.01) C07K 1/13 (2006.01)

Patent

CA 2290987

A method of ameliorating degradation of radiolabeled peptides, especially radiolabeled proteins such as antibodies, by including povidone, also widely known as polyvinylpyrrolidone or PVP, as a radioprotectant in a composition containing a radiolabeled peptide is described. A radioprotectant composition and a stable peptide-radioisotope composition having povidone are also described. Ascorbic acid or other secondary stabilizers may also be added to the compositions to further enhance radioprotection.

Procédé permettant de réduire la décomposition de peptides radio marqués, plus particulièrement de protéines radiomarquées tels que des anticorps, par l'incorporation de povidone également largement connus sous le nom de polyvinylpyrrolidone ou PVP, en tant que radio protecteur dans une composition contenant un peptide radiomarqué. On décrit également une composition de radioprotecteur et une composition stable de peptide-radioisotope contenant de la povidone. De l'acide ascorbique ou d'autres stabilisants secondaires peuvent également être ajoutés dans les compositions pour améliorer plus encore la radioprotection.

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