Radioprotectants targeting thrombospondin-1 and cd47

Details Radioprotectants targeting thrombospondin-1 and cd47 Radioprotectants targeting thrombospondin-1 and cd47

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61P 39/00 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2732102

Described herein is the discovery that cell and tissue survival can be dramatically increased following radiation ex-posure through inhibition of the interaction between TSP-1 and CD47. This effect is shown using antisense molecules, peptides, and antibodies, which can now be used as radioprotectant agents. These agents find application in minimizing, reducing and/or preventing tissue damage following intentional and accidental radiation exposure, as well as increasing the therapeutic efficacy of radiation therapies by protecting non-target tissue from incidental radiation damage and by increasing tumor ablation following radiation treatment.

La présente invention concerne la découverte que la survie cellulaire et tissulaire peut être fortement augmentée après exposition à un rayonnement par inhibition de linteraction entre TSP-1 et CD47. Cet effet est démontré en utilisant des molécules antisens, des peptides, et des anticorps qui peuvent désormais être utilisés en tant quagents radioprotecteurs. Ces agents ont une application dans la réduction au minimum et/ou la prévention de dommages tissulaires après une exposition au rayonnement intentionnelle et accidentelle, ainsi que laugmentation de lefficacité thérapeutique de radiothérapies par protection du tissu non-cible contre les dommages dus aux rayonnements incidents et par augmentation de lablation de tumeur après traitement par rayonnement.

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