A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 51/00 (2006.01)
Patent
CA 2616380
Methods and compositions are provided for treating or protecting a subject against the toxicities associated with ionizing radiation. The methods include administering to the subject a radioprotective amount of a radioprotective agent. The radioprotective agent includes an alpha-ketoalkanoic acid or a derivative thereof. For example, an ester of an alpha-ketoalkanoic acid, such as ethyl pyruvate, is used. The radioprotective agent may also comprise a superoxide dismutase, for example, EUK-134.
L'invention concerne des procédés et des compositions permettant de traiter ou de protéger un sujet contre les toxicités associées à un rayonnement ionisant. Les procédés consistent à administrer au sujet une quantité radioprotectrice d'un agent radioprotecteur. Celui-ci comprend un acide alpha-kétoalkanoïque ou un dérivé de celui-ci. Par exemple, un ester d'un acide alpha-kétoalkanoïque, tel que l'éthyle pyruvate, est utilisé. L'agent radioprotecteur peut également comprendre une superoxyde dismutase, par exemple, EUK-134.
Epperly Michael W.
Fink Mitchell P.
Greenberger Joel S.
Ridout & Maybee Llp
University Of Pittsburgh - Of The Commonwealth System Of Higher
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