Radiosensitization by cobalt and fe (iii) complexes

Details Radiosensitization by cobalt and fe (iii) complexes Radiosensitization by cobalt and fe (iii) complexes

A - Human Necessities

61

K

167/127

A61K 33/24 (2006.01) A61K 33/26 (2006.01)

Patent

CA 1277912

ABSTRACT OF THE DISCLOSURE The present invention relates to radiosensi- tization and, more particularly, to rendering hypoxic cells more sensitive to being killed by X-rays or other forms of irradiation. The specification discloses a pharmaceutical method and a composition containing a radiosensitizing amount of a Co(III) or Fe(III) coordination compound, selected from the group con- sisting of: (1) compounds having the formula - [CoNnX6-n]Y where n has a value of 3 or 4; N is an uncharged nitrogen donor atom that is contained in a ligand; X represents an anionic ligand; and y represents the charge on the complex; (2) compounds having the formula [CoA2X1D]Y where A represents a bidentate or tetradentate negative ligand containing N or O donor atoms; X and D represent the same or different monodentate ligands; and y1 represents a positive or negative charge on the complex; (3) compounds having the formula [CoZ3] where Z represents a chelating mononegative ligand; and (4) compounds of the formula [Fe TT1]+ where T and T1, which may be the same or different, represent mono-negative tridentate ligands.

520975

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