Radiotherapeutic immunoconjugates labeled with iodine-125

Details Radiotherapeutic immunoconjugates labeled with iodine-125 Radiotherapeutic immunoconjugates labeled with iodine-125

A - Human Necessities

61

K

167/101, 195/1.1

A61K 47/48 (2006.01) A61K 51/10 (2006.01)

Patent

CA 2000549

ABSTRACT OF THE DISCLOSURE A radiotherapeutic immunoconjugate comprising a tumor specific monoclonal antibody, or fragment thereof, and an Auger electron emitting radionuclide, wherein the tumor specific monoclonal antibody or fragment is capable of tumor nucleus localization of the radionuclide is disclosed. The radiotherapeutic immunoconjugate is administered in a therapeutically effective amount to patients having or suspected of having a malignancy reactive with the antibody or fragment.

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