C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/415 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 17/06 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07D 401/14 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2596973
Pyrazolyl compounds of Formulas Ia and Ib are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using pyrazolyl compounds for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
La présente invention concerne des composés pyrazolyle représentés par la formule Ia qui conviennent pour inhiber la kinase Raf et pour traiter des troubles induits par celle-ci. Cette invention concerne aussi des procédés d'utilisation des composés pyrazolyle de façon à diagnostiquer, prévenir ou traiter in vitro, in situ et in vivo ces troubles dans des cellules mammaliennes ou des états pathologiques associés.
Grina Jonas
Hansen Josh
Laird Ellen
Lyssikatos Joseph P.
Newhouse Brad
Array Biopharma Inc.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Genentech Inc.
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