Raf inhibitor compounds and methods of use thereof

Details Raf inhibitor compounds and methods of use thereof Raf inhibitor compounds and methods of use thereof

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/4985 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2609299

Compounds of Formula (I) are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using compounds of Formula (I), and stereoisomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

La présente invention concerne des composés représentés par la formule I qui conviennent pour inhiber la Raf kinase et pour traiter des troubles induits par celle-ci. Cette invention concerne aussi des procédés d'utilisation de ces composés et des stéréo-isomères, des tautomères, des solvates et des sels de ceux-ci répondant aux normes pharmaceutiques, destinés au diagnostic, in vivo, in situ et in vitro, à la prévention ou au traitement de ces troubles dans des cellules de mammifères ou d'états pathologiques associés.

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