Raf inhibitor compounds and methods of use thereof

Details Raf inhibitor compounds and methods of use thereof Raf inhibitor compounds and methods of use thereof

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/4355 (2006.01) A61K 31/4365 (2006.01) A61P 35/00 (2006.01) C07D 491/04 (2006.01)

Patent

CA 2620864

Compounds of Formula I are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using compounds of Formula I, and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

L'invention concerne des composés représentés par la formule I, destinés à inhiber la Raf kinase et à traiter des troubles impliquant celle-ci; des procédés d'utilisation des composés représentés par la formule I, ainsi que des stéréo-isomères, des isomères géométriques, des tautomères, des solvates et des sels pharmaceutiquement acceptables de ceux-ci, pour diagnostiquer, prévenir ou traiter in vitro, in situ et in vivo de tels troubles dans des cellules de mammifère, ou des états pathologiques associés.

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