Raf inhibitor compounds and methods of use thereof

Details Raf inhibitor compounds and methods of use thereof Raf inhibitor compounds and methods of use thereof

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 35/00 (2006.01) C07C 311/08 (2006.01)

Patent

CA 2716951

Compounds of Formula (I) are useful for inhibition of Raf kinases. Methods of using compounds of Formula (I) and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Des composés de formule I sont utiles pour inhiber des kinases RAF. La présente invention concerne des procédés d'utilisation de composés de formule I, ainsi que des stéréo-isomères, des tautomères, des promédicaments, et des sels pharmaceutiquement acceptables de ceux-ci, en vue du diagnostic, de la prévention, ou du traitement, in vitro, in situ, et in vivo, de ces troubles dans les cellules de mammifères. La présente invention concerne également des conditions pathologiques associées.

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