Raf inhibitors and their uses

Details Raf inhibitors and their uses Raf inhibitors and their uses

C - Chemistry, Metallurgy

07

D

C07D 498/04 (2006.01) A61K 31/424 (2006.01) A61K 31/429 (2006.01) A61P 35/00 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2744713

The present invention provides imidazooxazole and imidazothiazole compounds and their syntheses. The compounds of the present invention are capable of inhibiting the activity of RAF kinase, such as B-RAF v600E The compounds are useful for the treatment of cell proliferative disorders such as cancer.

La présente invention porte sur des composés imidazooxazole et imidazothiazole et sur leurs synthèses. Les composés de la présente invention sont capables d'inhiber l'activité de la kinase RAF, telle que B-RAFV600E. Les composés sont utilisés pour le traitement de troubles de la prolifération cellulaire tels que le cancer.

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