Raf kinase inhibitors containing a zinc binding moiety

Details Raf kinase inhibitors containing a zinc binding moiety Raf kinase inhibitors containing a zinc binding moiety

C - Chemistry, Metallurgy

07

D

C07D 213/62 (2006.01) A61K 31/44 (2006.01) A61P 35/00 (2006.01) C07D 213/75 (2006.01) C07D 213/78 (2006.01)

Patent

CA 2680398

The present invention relates to Raf kinase inhibitors containing zinc-binding and their use in the treatment of Raf related diseases and disorders such as cancer. The said derivatives may further act as HDAC inhibitors.

La présente invention concerne des inhibiteurs de la Raf kinase contenant un fragment de liaison au zinc et leur utilisation dans le traitement des maladies et des troubles associés à la Raf kinase, tels que le cancer. Lesdits dérivés peuvent également contenir des inhibiteurs HDAC.

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