Raf modulators and methods of use

Details Raf modulators and methods of use Raf modulators and methods of use

A - Human Necessities

61

K

A61K 31/4965 (2006.01)

Patent

CA 2565200

The present invention relates to compounds of the Formula I, wherein G, A, X1, X2, X3, Z, E, Y, and X are defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Raf. Methods of using and preparing the compounds, and pharmaceutical compositions thereof, to treat kinase-dependent diseases and conditions are also an aspect of the invention.

L'invention concerne des composés représentés par la formule I, G, A, X1, X2, X3, Z, E, Y, et X étant tels que définis dans le descriptif. Ces composés modulent l'activité enzymatique de la protéine kinase de manière à moduler les activités cellulaires telles que la prolifération, la différenciation, la mort cellulaire programmée, la migration et la chimio-invasion. Les composés décrits inhibent, régulent et/ou modulent les kinases, en particulier Raf. L'invention s'étend également à des méthodes d'utilisation et de préparation de ces composés, et de compositions pharmaceutiques comprenant ceux-ci, destinées au traitement des maladies et des troubles dépendant des kinases. (formule I)

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