A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4184 (2006.01) A61K 31/4164 (2006.01) A61P 25/28 (2006.01)
Patent
CA 2522275
Disclosed are RAGE antagonist compounds that have the ability to reverse pre- existing amyloidosis. Treatment with the RAGE antagonist compounds described herein may be used to reduce plaque size and improve cognition for subjects in the later stages of Alzheimer's disease. Additionally, the RAGE antagonists described herein may be used to reduce the onset of plaque formation and thereby prevent loss of cognition and other symptoms associated with Alzheimer's Disease and other diseases of amyloid deposition.
L'invention concerne des composés antagonistes RAGE pouvant agir contre une amylose préexistante. Le traitement à l'aide des composés antagonistes RAGE de l'invention peut être utilisé pour réduire la dimension des plaques, et améliorer la cognition chez des sujets se trouvant dans les stades ultimes de la maladie d'Alzheimer. Les antagonistes RAGE de l'invention peuvent être utilisés pour réduire l'apparition de la formation de plaques, et prévenir ainsi la perte de cognition et d'autres symptômes associés à la maladie d'Alzheimer, et d'autres maladies associées à un dépôt amyloïde.
Andrews Robert C.
Mjalli Adnan M. M.
Rothlein Robert
Shen Jane M.
Moffat & Co.
Transtech Pharma Inc.
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