Rage fusion proteins and methods of use

Details Rage fusion proteins and methods of use Rage fusion proteins and methods of use

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 38/17 (2006.01) A61K 47/48 (2006.01) C07K 14/705 (2006.01) C07K 16/00 (2006.01) C12N 15/12 (2006.01) C12N 15/13 (2006.01) C12N 15/62 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2638907

Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to an immunoglobulin CH2 domain. Such fusion proteins may provide specific, high affinity binding to RAGE ligands. Also disclosed is the use of the RAGE fusion proteins as therapeutics for RAGE- mediated pathologies.

La présente invention concerne des protéines hybrides RAGE contenant des séquences polypeptidiques RAGE liées à un second polypeptide non RAGE. Les protéines hybrides RAGE selon l'invention peuvent faire appel à un domaine polypeptidique RAGE contenant un site de liaison auxligands RAGE et un lieur interdomaine lié directement au domaine CH2 d'une immunoglobuline. De telles protéines hybrides peuvent présenter une affinité de liaison spécifique élevée pour les ligands RAGE. L'invention a également trait à l'utilisation des protéines hybrides RAGE selon l'invention pour traiter des pathologies induites par RAGE.

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