C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 38/00 (2006.01) A61K 38/17 (2006.01) A61K 47/48 (2006.01) A61P 3/10 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07K 14/705 (2006.01) C07K 16/46 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) C12N 15/13 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2570324
Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to an immunoglobulin CH2 domain. Such fusion proteins may provide specific, high affinity binding to RAGE ligands. Also disclosed is the use of the RAGE fusion proteins as therapeutics for RAGE- mediated pathologies.
La présente invention a trait à des protéines hybrides RAGE comportant des séquences polypeptidiques de RAGE liés à un deuxième polypeptide non RAGE. La protéine hybride RAGE peut utiliser un domaine polypeptidique RAGE comprenant un site de liaison de ligand RAGE et un lien interdomaine lié directement à un domaine C<SB>H</SB>2 d'immunoglobuline. De telles protéines hybrides peuvent assurer une liaison de haute affinité spécifique à des ligands RAGE. L'invention a également trait à l'utilisation des protéines hybrides RAGE comme agents thérapeutiques pour des pathologies induites par RAGE.
Mjalli Adnan M. M.
Rothlein Robert
Tian Ye Edward
Webster Jeffrey C.
Smart & Biggar
Transtech Pharma Inc.
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