Ragweed peptides for vaccine

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/35 (2006.01) A61K 39/00 (2006.01) A61K 39/36 (2006.01) A61P 37/08 (2006.01) C07K 7/04 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/415 (2006.01) C07K 14/435 (2006.01) G01N 33/50 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2734379

The present invention relates to compositions for preventing or treating allergy to ragweed by tolerisation. The compositions are based on combinations of peptide fragments derived from the major allergen in ragweed pollen, Amb a 1. The invention also relates to products, vectors and formulations which may be used to provide polypeptides of the invention in combination. The invention further relates to in vitro methods for determining whether T cells recognize a polypeptide of the invention, and for determining whether an individual has or is at risk of a condition characterized by allergic symptoms in response to a ragweed allergen.

La présente invention concerne des compositions pour prévenir ou traiter une allergie à l'ambroisie par l'augmentation de la tolérance. Les compositions se font avec des combinaisons de fragments peptidiques issus de l'allergène majeur dans le pollen d'ambroisie, Amb a 1. L'invention concerne également des produits, des vecteurs et des formulations qui peuvent être utilisés pour fournir des polypeptides de l'invention en combinaison. L'invention concerne en outre des procédés in vitro pour déterminer si des lymphocytes T reconnaissent ou non un polypeptide de l'invention, et pour déterminer si un individu présente ou est susceptible de présenter un état caractérisé par des symptômes allergiques en réponse à un allergène d'ambroisie.

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