Ramipril formulation with increased stability

Details Ramipril formulation with increased stability Ramipril formulation with increased stability

A - Human Necessities

61

K

A61K 9/20 (2006.01) A61K 9/48 (2006.01) A61K 31/403 (2006.01)

Patent

CA 2626613

A pharmaceutical formulation contains ramipril principally in the form of a ramipril salt and is buffered at basic pH. Ramipril in the formulation degrades preferentially to the diacid, ramiprilat, rather than the diketopiperazine.

L'invention concerne une préparation pharmaceutique contenant du ramipril essentiellement sous la forme d'un sel de ramipril, cette préparation étant tamponnée à un pH basique. Le ramipril dans la préparation se dégrade de préférence en diacide ou en ramiprilate plutôt qu'en dicétopipérazine.

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