Ranbp2 as modifier of the pten/igf pathway and methods of use

Details Ranbp2 as modifier of the pten/igf pathway and methods of use Ranbp2 as modifier of the pten/igf pathway and methods of use

G - Physics

01

N

G01N 33/53 (2006.01)

Patent

CA 2524130

Human RANBP2 genes are identified as modulators of the PTEN/IGF pathway, and thus are therapeutic targets for disorders associated with defective PTEN/IGF function. Methods for identifying modulators of PTEN/IGF, comprising screening for agents that modulate the activity of RANBP2 are provided.

Selon l'invention, des gènes humains RANBP2 sont identifiés en tant que modulateurs de la voie PTEN/IGF et, de ce fait, constituent des cibles thérapeutiques pour des troubles associés à une fonction PTEN/IGF défectueuse. L'invention concerne également des méthodes d'identification de modulateurs de PTEN/IGF consistant à cribler des agents qui modulent l'activité de RANBP2.

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