Random rnai libraries, methods of generating same, and...

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01) C40B 50/00 (2006.01)

Patent

CA 2644995

This invention provides expression vectors for a ribonucleic acid (RNA) molecule comprising a double-stranded region of random sequence, sets and libraries of same, methods of generating same, and methods for identifying an RNA therapeutic or RNA molecule that has an ability to affect a biological parameter, for identifying a drug target for a disease or disorder of interest, and for identifying a variant of an RNA molecule that has an altered ability to affect a biological parameter of interest.

La présente invention concerne des vecteurs d'expression pour une molécule d'acide ribonucléique (ARN) comprenant une région double brin d'une séquence aléatoire, des ensembles et des banques de telles molécules, des procédés permettant leur génération, et des procédés d'identification d'un agent thérapeutique ARN ou d'une molécule ARN ayant la capacité d'affecter un paramètre biologique, permettant d'identifier un médicament cible pour une maladie ou un trouble d'intérêt, et permettant d'identifier un variant d'une molécule ARN qui possède la capacité altérée d'affecter un paramètre biologique d'intérêt.

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