Rapalogs, pharmaceutical compositions, preparation methods...

Details Rapalogs, pharmaceutical compositions, preparation methods... Rapalogs, pharmaceutical compositions, preparation methods...

C - Chemistry, Metallurgy

07

D

C07D 498/18 (2006.01) A61K 31/436 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01)

Patent

CA 2737355

Rapalogs of formula I, pharmaceutically acceptable salts, pharmaceutical compositions, and preparation methods and uses thereof. The rapalogs have the structure of formula I and can be used as an anti-tumor medicament. Comparing with rapamycin, the rapalogs of the present invention exhibit enhanced water solubility, and improved pharmacological and pharmacokinetic properties by introducing a hydrophilic and polar group such as a hydroxyl. (see above formula)

Linvention concerne un produit similaire à lester de carbonate de Sirolimus de formule I, son sel et son composé médicinal pharmaceutiquement acceptables, son procédé de préparation et son utilisation. Ledit produit de structure I peut être utilisé comme médicament pour lutter contre les tumeurs. Des caractéristiques du produit similaire à lester de carbonate de Sirolimus de formule I telles que sa solubilité dans leau, ses propriétés pharmacologiques et ses propriétés pharmacocinétiques ont été améliorées par rapport au Sirolimus.

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