Rapamycin carbohydrate derivatives

Details Rapamycin carbohydrate derivatives Rapamycin carbohydrate derivatives

C - Chemistry, Metallurgy

07

H

C07H 15/04 (2006.01) A61F 2/02 (2006.01) A61K 31/436 (2006.01) C07D 498/18 (2006.01)

Patent

CA 2525907

This invention provides modified rapamycins that have specific monosaccharide(s), oligosaccharide(s), pseudosugar(s) or derivatives thereof attached through a linker to create rapamycin carbohydrate derivatives having enhanced pharmacokinetic and/or pharmacodynamic profiles. For example, administration of the rapamycin carbohydrate derivative results in altered pharmacokinetic profiles and reduced toxicities. Thus, the present invention provides compounds with characteristics that are distinct from other drugs in its class such as rapamycin.

L'invention concerne des rapamycines modifiées contenant un/des monosaccharide(s), oligosaccharide(s), pseudosaccharide(s) spécifiques, ou des dérivés de ceux-ci, relié(s) par un lieur de sorte à créer des dérivés de rapamycine carbohydrate présentant des profils pharmacocinétiques et/ou pharmacodynamiques améliorés. L'administration d'un dérivé de rapamycine carbohydrate entraîne, par exemple, la modification du profil pharmacocinétique et la réduction de la toxicité. La présente invention concerne donc des composés dont les caractéristiques sont différentes des autres médicaments de cette catégorie, tels que la rapamycine.

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