Rapamycin dimers

Details Rapamycin dimers Rapamycin dimers

C - Chemistry, Metallurgy

07

H

C07H 19/01 (2006.01) C07D 498/18 (2006.01) C07D 519/00 (2006.01) A61K 31/71 (1990.01)

Patent

CA 2069468

AHP-9808 ABSTRACT A rapamycin dimer of general formula (1) Image (I) wherein A is -(CH2)n-, -(CH2)n-(CH=CH)-(CH2)m-, -(CH2)n-(-C?C-)-(CH2)m-, Image Image , substituted alkyl, substituted alkenyl, substituted alkynyl, and substituted aromatic; n = l-lO, m = l-lO and n = m or n ? m or a pharmaceutically acceptable salt thereof, which is by virtue of its immunosuppressive activity is useful in treating transplantation rejection host vs. graft disease, autoimmune diseases, and diseases of inflammation.

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