Rapamycin formulation for iv injection

Details Rapamycin formulation for iv injection Rapamycin formulation for iv injection

A - Human Necessities

61

K

A61K 31/436 (2006.01) A61K 31/435 (2006.01) A61K 47/10 (2006.01) A61K 47/26 (2006.01) A61K 47/32 (2006.01) A61K 9/02 (2006.01) A61K 31/445 (2006.01) A61K 31/71 (1990.01)

Patent

CA 2133179

Abstract of the Disclosure Disclosed herein is an aqueous, injectable rapamycin solution, obtainable by a process comprising mixing 5 to 30 volume percent of a concentrate solution of rapamycin in propylene glycol, at concentrations of rapamycin ranging from 0.5 mg/ml to 10 mg/ml, with a diluent solution comprising 0.1 to 10 weight percent of one or more polyoxyethylene sorbitan esters, 10 to 60 weight percent of polyethylene glycol 200, 300 or 400 or a combination thereof and 30 to 89.9 volume percent water, wherein the concentration of rapamycin in the injectable solution ranges from 0.025 mg/ml to 3 mg/ml. Also disclosed is a pharmaceutical product containing such concentrate solutions of rapamycin and such diluent solutions, as a combined preparation for mixing prior to IV injection to give an aqueous, injectable rapamycin solution having a concentration of rapamycin ranging from 0.025 mg/ml to 3 mg/ml.

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