C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/0783 (2010.01) A61K 35/14 (2006.01) A61P 35/00 (2006.01) A61P 37/06 (2006.01)
Patent
CA 2529244
Methods for generating highly enriched Thl/Tcl and Th2/Tc2 functions are described. In particular, the generation of these functions are attained by the addition of an immune suppression drug, rapamycin or a rapamycin derivative compound. In addition to enhanced purity of T cell function, the T cells generated in rapamycin also express molecules that improve immune T cell function such as CD28 and CD62L. Such rapamycin generated functional T cell subsets may have application in the prevention or treatment of GVHD after allogeneic hematopoietic stem cell transplantation, the treatment of autoimmunity, or the therapy of infection or cancer.
L'invention concerne des méthodes de génération de fonctions Th1/Tc1 et Th2/Tc2 hautement enrichies. En particulier, la génération de ces fonctions est obtenue par l'addition d'un médicament immunodépresseur, la rapamycine ou un composé dérivé de rapamycine. En plus d'une pureté accrue de la fonction lymphocytes T, les lymphocytes T générés dans la rapamycine expriment également des molécules améliorant la fonction lymphocytes T immune telle que CD28 et CD62L. Lesdits sous-ensembles de lymphocytes T fonctionnels générés par rapamycine peuvent avoir une application dans la prévention ou dans le traitement de la réaction de greffe contre hôte GVHD après transplantation de cellules souches hématopoïétiques allogéniques, le traitement de l'auto-immunité ou la thérapie d'infections ou du cancer.
Fowler Daniel H.
Gress Ronald E.
June Carl
Jung Unsu
Levine Bruce
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Department Of Health And Human Services Government Of The United States Of America As Represented By The
The Trustees Of The University Of Pennsylvania
LandOfFree
Rapamycin resistant t cells and therapeutic uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Rapamycin resistant t cells and therapeutic uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Rapamycin resistant t cells and therapeutic uses thereof will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-2004950